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. Author manuscript; available in PMC: 2019 Nov 6.
Published in final edited form as: Structure. 2018 Sep 6;26(11):1499–1512.e5. doi: 10.1016/j.str.2018.07.012

Figure 2. Structure-Based Sequence Alignment of hDHS (PDB: 1DHS), TbDHSc, and TbDHSp.

Figure 2.

Residues highlighted show the NAD+ binding site (yellow), spermidine/GC7 binding site (cyan), and both ligands (green) from hDHS (PDB: 1RQD). The catalytic Lys is identified with the symbol ¥. Residues targeted for TbDHSc:DHSp mutagenesis are indicated with arrows. Helices are labeled with “H” and α sheets with “B.” B1* and B3* are found only in DHSc, H1’ is only in hDHS, and H6Λ^ is in both hDHS and DHSp. Structural alignment by PROMALS3D (Pei et al., 2008). Residues not resolved in the structure are underlined.