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. 2018 Nov 1;9:2515. doi: 10.3389/fimmu.2018.02515

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Copyright © 2018 Veremeyko, Yung, Anthony, Strekalova and Ponomarev.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kinetics of expression of Egr1, Egr2, and Egr3, M2 marker Arg1, and M1 marker NOS2 in macrophages polarized toward M2 (IL-4), or M1 (IFNγ). Bone-marrow-derived macrophages (BMDMs) were analyzed as untreated (C) or treated with IL-4 (IL4) or IFNγ (IFN) as described in Materials and Methods. The cells were analyzed after 3, 5, 8, and 24 h of incubation with indicated cytokines. For analysis, the cells were washed, mRNA was isolated and the expressions of Arg1 (A), Nos2 (B), Egr1 (C), Egr2 (D), and Egr3 (E) were analyzed by real-time RT PCR as described in Materials and Methods. Mean ± S.E. of 12 separate culture plate wells is shown [^*p < 0.05; ^**p < 0.01; ^***p < 0.001; ^****p < 0.0001 when compared to untreated (C) cells].

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