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. 2018 Nov 1;9:2543. doi: 10.3389/fimmu.2018.02543

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Copyright © 2018 Salerno-Gonçalves, Galen, Levine, Fasano and Sztein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytokine production after stimulation with different S. Typhi strains. Cells from the 3-D model were untreated (none) or exposed to CVD 908, CVD 909, CVD 910, CVD 915, Ty2, or Ty21a S. Typhi strains. After 4 h, levels of cytokines in the cultures supernatants were measured by using the commercial Meso Scale Discovery (MSD) multiplex-assay. Bar graphs extend from the 25 to 75th percentiles, and the line in the middle represents the median of the pooled data. The whiskers delineate the smallest to the largest value. The data represent up to 6 individual experiments for each of S. Typhi strains with one or two replicates. Horizontal lines represent significant differences (p < 0.05) between the indicated culture conditions.