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. 2018 Nov 1;9:2543. doi: 10.3389/fimmu.2018.02543

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Copyright © 2018 Salerno-Gonçalves, Galen, Levine, Fasano and Sztein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Profile of cytokine response after stimulation with different S. Typhi strains. Cells from the 3-D model were untreated (none) or exposed to CVD 908, CVD 909, CVD 910, CVD 915, Ty2, or Ty21a S. Typhi strains. After 4 h, the levels of IL-1-β, IL-6, IL-8, IL-17A, and TNF-α cytokines in the cultures supernatants were measured by the commercial Meso Scale Discovery (MSD) multiplex-assay. (A) Spider plot and (B) heat map of the mean values of the cytokines. (C) Correlation between IL-17A and the other pro-inflammatory cytokine levels in the supernatants from 3-D mucosa organoids after stimulation with the different S. Typhi strains. Correlations used the Pearson Product Moment tests. The data represent up to six individual experiments for each of S. Typhi strains with one or two replicates. P-values < 0.05 were considered significant.