Table 5.
Results of linear and logistic regression modelsa showing the relationship between maternal TCDD exposure and length of gestation and fetal growth, SWHS, Seveso, Italy, 1976–2014.
| Gestational age (weeks) |
Preterm |
Birthweight (grams) |
Small-for-Gestational-Age |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Exposure | Pregnancies | N | Adj. β (95% CI)b | n/Total | Adj. OR (95% CI)b | n | Adj. β (95% CI) | n/Total | Adj. β (95% CI) |
| 1976 Serum | All | 834 | −0.37 (−1.84, 1.10) | 47/834 | 1.18 (0.71, 1.94) | 834 | −38.2 (−100.2, 23.7)c | 74/834 | 1.33 (0.92, 1.94)c |
| TCDD | First | 516 | −0.86 (−2.61, 0.90) | 32/516 | 1.17 (0.66, 2.08) | 516 | −60.5 (−130.4, 9.5)c | 52/516 | 1.39 (0.90, 2.15)c |
| TCDD at | All | 834 | 0.94 (−0.73, 2.60) | 47/834 | 0.68 (0.35, 1.36) | 834 | 28.4 (−41.7, 98.5)d | 74/834 | 1.21 (0.75, 1.94)d |
| Pregnancy | First | 516 | 0.44 (−1.42, 2.30) | 32/516 | 0.69 (0.33, 1.45) | 516 | −5.5 (−87.5, 76.6)d | 52/516 | 1.40 (0.82, 2.37)d |
| TEQ at | All | 228 | 9.6 (3.3, 15.8) | 17/228 | 0.09 (0.01, 1.06) | 228 | 235.1 (−17.6, 487.7)d | 15/228 | 1.53 (0.10, 22.85)d |
| Pregnancy | First | 113 | 8.5 (−1.8, 18.8) | 12/113 | 0.10 (0.01, 1.68) | 113 | 295.7 (−102.3, 693.8)d | 7/113 | 0.96 (0.01, 154.2)d |
a
Results are for a 10-fold increase in serum TCDD or TEQ.
b
Adjusted for maternal height, pre-explosion history of low birthweight, year of pregnancy, parity, and maternal age.
c
Adjusted for maternal height, pre-explosion history of low birthweight, year of pregnancy, parity, maternal age, maternal smoking.
d
Adjusted for maternal height, pre-explosion history of low birthweight, year of pregnancy, parity, maternal age, maternal smoking, gestational weight gain.