Table 3.
Mean (standard deviation) fiber densities of hippocampal subfields
| All patients (n=25) | Temporal Onset (n=19) | Left Temporal Onset (n=9) | Right Temporal Onset (n=5) | Control (n=25) | |
|---|---|---|---|---|---|
| Left Hemisphere | |||||
| Tail | 9.99 (4.48) | 10.14 (4.67) | 11.57 (4.84) | 8.65 (4.27) | 9.06 (4.51) |
| Subiculum | 14.35 (5.20) | 13.39 (5.44) | *14.28 (7.01) | 14.12 (4.01) | 11.61 (5.22) |
| CA1 | 2.72 (0.86) | 2.61 (0.74) | 2.81 (0.67) | 2.46 (0.90) | 2.44 (1.12) |
| Fissure | 0.44 (1.06) | 0.53 (1.21) | 0.20 (0.31) | 1.30 (2.19) | 0.52 (1.28) |
| Presubiculum | *2.23 (1.82) | 2.09 (1.77) | *3.35 (1.76) | 1.32 (0.75) | 1.03 (0.57) |
| Parasubiculum | 39.23 (21.42) | 36.48 (20.05) | *46.48 (21.10) | 29.27 (16.60) | 27.12 (16.88) |
| Molecular layer | 1.57 (0.73) | 1.47 (0.66) | 1.63 (0.73) | 1.45 (0.67) | 1.46 (0.44) |
| GC-ML-DG | 0.42 (0.57) | 0.35 (0.51) | 0.20 (0.31) | 0.66 (0.94) | 0.46 (0.49) |
| CA3 | 11.61 (6.43) | 11.22 (7.15) | *14.48 (6.60) | 0.90 (8.06) | 9.44 (4.53) |
| CA4 | 11.51 (4.18) | 11.38 (4.55) | *14.51 (4.08) | 7.88 (3.40) | 11.65 (3.94) |
| Fimbria | 7.94 (4.44) | 8.29 (4.54) | 9.14 (5.20) | 9.65 (4.37) | 6.46 (4.04) |
| HATA | 8.62 (6.81) | 8.05 (6.43) | 11.39 (7.99) | 4.68 (1.52) | 9.38 (4.32) |
| Whole Hippocampus | 6.70 (2.12) | 6.68 (2.06) | 7.83 (1.91) | 5.93 (1.61) | 5.79 (1.86) |
| Right Hemisphere | |||||
| Tail | 34.98 (16.25) | 34.82 (17.09) | 34.77 (12.67) | 33.89 (28.87) | 40.03 (15.25) |
| Subiculum | 42.15 (18.43) | 41.96 (20.00) | *39.18 (15.62) | 43.90 (32.31) | 50.34 (18.28) |
| CA1 | 14.42 (7.39) | 14.55 (7.84) | *12.85 (3.73) | 14.60 (12.77) | 18.87 (9.15) |
| Fissure | 2.48 (2.70) | 2.58 (2.90) | 1.82 (1.81) | 1.73 (2.00) | 1.81 (2.70) |
| Presubiculum | 3.62 (2.14) | 3.60 (2.12) | 4.01 (2.01) | 3.23 (1.47) | 3.41 (4.93) |
| Parasubiculum | 66.70 (67.64) | 53.90 (25.63) | 61.84 (31.83) | 45.39 (18.80) | 59.33 (53.78) |
| Molecular layer | 4.02 (1.74) | 3.93 (1.80) | 4.24 (0.96) | 4.49 (3.18) | 3.40 (2.31) |
| GC-ML-DG | 1.03 (0.90) | 1.06 (0.88) | 1.15 (0.83) | 1.46 (1.23) | 1.37 (1.75) |
| CA3 | 22.18 (15.81) | 22.07 (17.35) | 19.56 (7.54) | 29.06 (33.07) | 20.32 (11.06) |
| CA4 | 46.65 (17.65) | 48.55 (18.54) | 48.47 (7.31) | 43.80 (26.55) | 52.59 (27.68) |
| Fimbria | 18.92 (12.68) | 19.19 (13.28) | 17.48 (7.06) | 23.65 (24.94) | 16.25 (9.11) |
| HATA | 8.89 (4.84) | 9.77 (5.22) | 10.00 (5.39) | 8.89 (1.39) | 11.33 (7.52) |
| Whole Hippocampus | 20.47 (7.72) | 20.41 (8.55) | *19.77 (4.94) | 20.93 (15.95) | 23.48 (6.64) |
*
significant after FDR correction, CA: Cornu Ammonis, GC-ML-DG: granule cell layer of dentate gyrus, HATA: hippocampal-amygdala transition area