Fig. 3.

Apigenin reduces proliferation of Ishikawa cells independently of progesterone receptor. a–b Proliferation of Ishikawa PR-B cells in response to progesterone (a) or apigenin (b). c Proliferation of Ishikawa null cells treated with apigenin. d Proliferation of Ishikawa PR-B cells treated with apigenin and Ru486 as indicated. e Proliferation of Ishikawa PR-B cells treated with apigenin in the presence of progesterone. n ≥ 3. Significantly different from 0 μM or control, *P < 0.05, **P < 0.01. ****P < 0.0001