Table 4.

Top 10 Significant Radiomic Features Ranked According to the Concordance Index (C-Index)

Statistic	MR Imaging	Radiomic Feature	C-Index	P Value	Hazard Ratio*	95% Confidence Interval
skewness	T2w	Haralick correlation	0.74	<0.0001	2.09	1.52 – 2.87
kurtosis	ADC	CoLlAGe entropy	0.72	<0.0001	2.28	1.65 – 3.16
variance	T2w	Haralick differential average	0.72	<0.0001	1.85	1.39 – 2.46
variance	T2w	Haralick inertia	0.71	<0.0001	1.56	1.21 – 2.02
kurtosis	ADC	CoLlAGe sum entropy	0.71	0.0001	2.27	1.61 – 3.19
skewness	ADC	CoLlAGe energy	0.71	<0.0001	2.20	1.57 – 3.09
skewness	ADC	CoLlAGe info 1	0.70	0.0001	0.50	0.36 – 0.70
variance	T2w	Haralick differential variance	0.70	<0.0001	1.51	1.17 – 1.95
kurtosis	ADC	CoLlAGe energy	0.70	<0.0001	1.93	1.44 – 2.58
kurtosis	T2w	Haralick sum variance	0.69	<0.0001	1.59	1.26 – 2.01

Note. —ADC = apparent diffusion coefficient; CoL1AGe = co-occurrence of local anisotropic gradient orientation; T2WI = T2-weighted imaging.

^*Obtained from Cox proportional hazards model univariate analysis.