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Scheme depicting CNP-induced generation of cGMP by Npr2 in the wild-type and the effect of the Npr2-7A and Npr2–7E mutants (A–C) and the corresponding axon branching phenotype (D) of sensory neurons. Although phosphorylation is mimicked by glutamic acid substitutions, Npr2–7E does not generate cGMP in the absence of the ligand CNP. Npr2 dimers display only one catalytic site (Robinson and Potter, 2012).
