Table 1.
List of inhibitors that block SFA-induced CHOP expression
| Inhibitor name | CHOP expression (ratio to C18:0 with vehicle) | |
|---|---|---|
| Olomoucine | Cyclin-dependent kinases (CDK) inhibitor | 0.63 |
| INK128 | TORC1/2 inhibitor | 0.59 |
| PI3Kα inhibitor 2 | Phosphatidylinositol 3-kinase (PI3Kα) inhibitor | 0.59 |
| CAY10574 | CDK9 and CDK2-cyclin E inhibitor | 0.50 |
| Torin 1 | mTOR selective inhibitor | 0.28 |
| Kenpaullone | CDKs and glycogen synthase kinase 3β (GSK3β) inhibitor | 0.19 |
| 5-Iodotubercidin | Nonspecific PK inhibitor | 0.19 |
| Bisindolylmaleimide IX (mesylate) | Protein kinase C (PKC) isoforms inhibitor | 0.19 |
| NSC 663284 | Cdc25 isoforms inhibitor | 0.18 |
| Wortmannin | PI3K enzymes inhibitor | 0.17 |
| PHA-767491 | CDK7/CDK9 kinase inhibitor | 0.17 |
| GSK1059615 | PI3Kα inhibitor | 0.17 |
| BIBF 1120 | Tyrosine kinase inhibitor | 0.14 |
| Dinaciclib | pan-CDK inhibitor | 0.14 |
| AT7519 | pan-CDK inhibitor | 0.13 |
| Flavopiridol | pan-CDK inhibitor | 0.02 |
| C18:0 with vehicle | BSA | 1.00 |
| Vehicle | BSA | 0.15 |