Fig. 6.

Co-treatment with MnP and dox increases cell area. MCF7 and MDA-MB-231 cell spread on matrigel was monitored over time (A and D). Cells treated with the indicated drugs for 16 h (B and E) or 30 min (C and F) were seeded on matrigel-coated transwells and allowed to spread. The cells were left to adhere for 12 h and cell area was measured. Data is summarized in B, C, E and F. Cell area determined from at least three independent experiments (n > 50 cells per condition and per experiment) and are shown as means ± SEM. *p < 0.05, **p < 0.01 (one-way ANOVA with Tukey's test, relative to untreated cells).