Table 1.
Demographic, clinical, and genetic results of anti-Jo-1 positive patients.
| Anti-Jo-1 positive patients | HLA-DRB1 ∗ 03 positive patients | HLA-DRB1 ∗ 03 negative patients | p value | ||||
|---|---|---|---|---|---|---|---|
| Number of patients: | 49 | 20 | 9 | - | |||
| Male/Female: | 7/42 | 1/19 | 2/7 | 0.22 | |||
| Average age at disease onset ± SD (youngest-oldest): | 43.4 ±13.28 (18-70) |
40.4±13.9 | 40.22±14.55 | 0.703 | |||
| Median follow-up time ± SD (years) | 10.1 ±6.51 | 11.5±6.79 | 12.33±5.34 | 0.748 | |||
|
| |||||||
| Average CK at diagnosis (U/l) ± SD | 3003.25 ±3101.8 | 2816.30 ±2417.36 | 5969.44 ±3842.89 | 0.045 | |||
| Average LDH at diagnosis (U/l) ± SD | 922.33 ±635.32 | 891.78±661.3 | 1292.57 ±737.948 | 0.2 | |||
| Average CRP at diagnosis (mg/l) ± SD | 22.49 ±22.09 | 18.32±22.55 | 23.99±17.17 | 0.542 | |||
| Average ESR at diagnosis (mm/h) ± SD | 24.24 ±15.96 | 21.50±13.57 | 24.89±14.46 | 0.547 | |||
|
| |||||||
| myositis: | 49/49 | 100% | 20/20 | 100% | 9/9 | 100% | 1.0 |
| ILD/alveolitis: | 35/48 | 73% | 15/20 | 75% | 7/9 | 78% | 1.0 |
| arthritis/arthralgia: | 43/49 | 88% | 16/20 | 80% | 8/9 | 89% | 1.0 |
| dysphagia: | 6/49 | 12% | 3/20 | 15% | 1/9 | 11% | 1.0 |
| fever: | 21/49 | 43% | 7/20 | 35% | 6/9 | 67% | 0.226 |
| Raynaud's phenomenon: | 32/49 | 65% | 10/20 | 50% | 8/9 | 89% | 0.096 |
| mechanic's hand: | 16/49 | 33% | 5/20 | 25% | 5/9 | 56% | 0.205 |
| subcutaneous calcinosis: | 3/49 | 6% | 1/20 | 5% | 1/9 | 11% | 0.532 |
| SSA positivity: | 17/49 | 35% | 7/20 | 35% | 2/9 | 22% | 0.675 |
| mortality: | 5/49 | 10% | 3/20 | 15% | 0/9 | 0% | 0.532 |
| Maintenance dose of steroid (mg): | 5.57±8.44 | 3.90±3.81 | 3.44±3.644 | 0.765 | |||