Table 2.
Detailed comparison of anti-Jo-1+/anti-SSA+ and anti-Jo-1+/anti-SSA-patients.
| SSA positive patients | SSA negative patients | p | |||
|---|---|---|---|---|---|
| Demographic data | |||||
|
| |||||
| Number of patients: | 17 | 32 | - | ||
| Male/female: | 1/16 | 6/26 | 0.397 | ||
| Average age at disease onset ± SD (youngest-oldest): |
36.12±11.08 (21-58) |
47.22±12.87 (18-70) |
0.004 | ||
|
| |||||
| Laboratory parameters | |||||
|
| |||||
| Average CK at diagnosis (U/l) ± SD: | 3484.87±3549.27 | 2754.14±2878.91 | 0.465 | ||
| Average LDH at diagnosis (U/l) ± SD: | 871.33±491.29 | 949.64±707.46 | 0.705 | ||
| Average CRP at diagnosis (mg/l) ± SD: | 24.76±22.21 | 21.18±22.35 | 0.623 | ||
| Average ESR at diagnosis (mm/h) ± SD: | 26.94±19.34 | 22.81±13.98 | 0.394 | ||
|
| |||||
| Clinical symptoms | |||||
|
| |||||
| Myositis: | 17 | 100% | 32 | 100% | 1 |
| Interstitial lung disease: | 9 | 53% | 26 | 81% | 0.039 |
| Arthritis: | 15 | 88% | 28 | 88% | 1 |
| Raynaud's phenomenon: | 13 | 76% | 19 | 59% | 0.231 |
| Dysphagia: | 2 | 12% | 4 | 13% | 1 |
| Fever: | 10 | 59% | 11 | 34% | 1 |
|
| |||||
| Skin lesions (all): | 9 | 53% | 18 | 56% | 1 |
|
| |||||
| there from: | |||||
| Mechanic's hand: | 6 | 35% | 10 | 31% | 0.774 |
| Gottron-papule: | 2 | 12% | 4 | 13% | 1 |
| Gottron-sign: | 2 | 12% | 4 | 13% | 1 |
| Scarf –sign: | 1 | 6% | 1 | 3% | 1 |
| V-sign: | 2 | 12% | 2 | 6% | 0.607 |
| Heliotrope rash: | 0 | 0 | 3 | 9% | 0.542 |
| Periorbital oedema: | 1 | 6% | 2 | 6% | 1 |
| Alopecia: | 1 | 6% | 2 | 6% | 1 |
| Vasculitis-like skin lesion: | 3 | 18% | 3 | 9% | 0.405 |
| Livedo reticularis: | 3 | 18% | 1 | 3% | 0.114 |
| Skin erosion: | 3 | 18% | 0 | 0 | 0.037 |
| Teleangiectasia: | 1 | 6% | 5 | 16% | 0.65 |
| Subcutaneous calcinosis: | 1 | 6% | 2 | 6% | 1 |
|
| |||||
| Therapy | |||||
|
| |||||
| Maintenance dose of steroid (mg) ± SD: | 9.53±12.56 | 3.47±3.95 | 0.031 | ||
SSA: Sjögren's-syndrome-related antigen A; SD: standard deviation; CK: creatine kinase; LDH: lactate dehydrogenase; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate.