Table 1.

Effects on cytokine productions by commonly used drugs.

	IL-1	IL-6	IL-8	TNF-α	IFN-γ	IL-2	IL-4	IL-12	IL-18	TNF-β	IL-3	IL-5	IL-10	IL-13
H2 receptor antagonist
NSAIDs
Prostaglandin
Norfloxacin		↓		↓									↑
Linezolid	↓	↓	↓	↓	↓								↑
Macrolide	↓		↓or↑	↑	↓	↓	↓or↑		↓or↑			↓or↑		↓or↑
Antifungal drugs		↑			↑	↑				↓			↓
β2 adrenalin agonist
D2 receptor agonist
ACE inhibitor				↓
ARB				↓	↓
Ca channel blocker	↓or↑	↓or↑		↓	↓	↑
Digoxin
DPP4 inhibitor
GLP-1 receptor agonist					↓		↓
Biguanide
Statin				↓