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. 2018 Nov;188(11):2653–2661. doi: 10.1016/j.ajpath.2018.07.012

Figure 2.

Figure 2

A and B: Histologic features of tumors in Tg-STRN-ALK mice without (A) and with (B) goitrogen treatment. C: Microscopic appearance of mouse and human STRN-ALK–positive poorly differentiated thyroid cancer showing tumor areas composed of confluent sheets of round- or spindle-shaped cells. Arrows show mitotic figures. Scale bar = 50 μm (A–C). Original magnifications: ×100 (A and B, top panels); ×400 (A–C, bottom panels); ×200 (C, top panels). PDTC, poorly differentiated thyroid carcinoma.