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Immunohistochemical characterization of thyroid tumors developed in Tg-STRN-ALK mice with and without goitrogen treatment. The tumors demonstrate the expression of hemagglutinin (HA) that tags STRN-ALK, as well as positive staining for thyroid-specific factor TTF1, indicating thyroid follicular epithelial cell origin. High proliferation rate of tumor cells is indicated by Ki-67 immunostaining. Scale bars = 100 μm. Original magnification, ×200. H&E, hematoxylin and eosin.
