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Immunohistochemical features of dedifferentiation in STRN-ALK–positive mouse tumors. Poorly differentiated tumor cells preserve expression of TTF1 but show decreased expression or complete loss of thyroglobulin and E-cadherin in focal areas of the tumor showing lack of follicular architecture on hematoxylin and eosin (H&E) staining. Scale bar = 100 μm. Original magnifications: ×40 (top row); ×200 (bottom row).
