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OARSI osteoarthritis cartilage histopathology scoring.
| Grade (key feature) | Stage % Involvement (surface, area, volume) |
|||
|---|---|---|---|---|
| Stage 1 (<10%) | Stage 2 (10–25%) | Stage 3 (25–50%) | Stage 4 (>50%) | |
| Grade 1 (surface intact) | 1 | 2 | 3 | 4 |
| Grade 2 (surface discontinuity) | 2 | 4 | 6 | 8 |
| Grade 3 (vertical fissures, clefts) | 3 | 6 | 9 | 12 |
| Grade 4 (erosion) | 4 | 8 | 12 | 16 |
| Grade 5 (denudation) | 5 | 10 | 15 | 20 |
| Grade 6 (deformation) | 6 | 12 | 18 | 24 |
| Score = grade × stage | ||||
