Table 1.
Chromatographic retention (k’) and enantioselectivity (α) of various MIP-CSPs tested in slurry packed columns (S1–11).
| # | T (mmol) | M(s) (mmol) | Me (mmol) | C (mmol) | Molar Ratio T:M:Me:C | A (mmol) | P (mL) | k’S/k’R | α |
|---|---|---|---|---|---|---|---|---|---|
| S1 | S-ATNL (0.3) | NOBE (7.6) | - | - | 1:25:-:- | - | DMF (4) | 33.2/31.6 | 1.05 a |
| S2 | S-ATNL (0.3) | NOBE (7.6) | Cu(II) (0.3) | - | 1:25:1:- | - | DMF (4) | 33.2/31.6 | 1.05 a |
| S3 | S-ATNL (0.3) | NOBE (7.6) | Co(II) (0.3) | - | 1:25:1:- | - | DMF (4) | 36.8/36.3 | 1.01 a |
| S4 | S-ATNL (0.3) | NOBE/MAA (7.6/1) | - | - | 1:25/3:-:- | - | ACN (2) | 4.4/3.8 | 1.17 b |
| S6 | S-ATNL (0.3) | 4-VPy (0.3) | Co(II) (0.3) | TRIM (7.3) | 1:1:1:24 | - | DMF/DMSO (2/2) | 3.6/3.5 | 1.03 a |
| S7 | S-ATNL (0.3) | 4-VPy (1.5) | Co(II) (0.3) | TRIM (6.1) | 1:5:1:20 | - | DMF/DMSO (2/2) | 8.2/7.9 | 1.04 a |
| S8 | S-ATNL (0.3) | 4-VPy (3) | Co(II) (0.3) | TRIM (4.6) | 1:10:1:15 | - | DMF/DMSO (2/2) | 8.2/7.9 | 1.04 a |
| S9 | S-ATNL (0.3) | 4-VPy/AM (0.3/1.2) | Co(II) (0.3) | TRIM (6.1) | 1:1/4:1:20 | - | DMF/DMSO (2/2) | 0.5/0.5 | 1.00 |
| S10 | S-ATNL (0.3) | 4-VPy/BAM (0.3/1.2) | Co(II) (0.3) | TRIM (6.1) | 1:1/4:1:20 | - | DMF/DMSO (2/2) | 0.6/0.5 | 1.07 a |
| S11 | S-ATNL (0.15) | 4-VPy (0.9) | Co(II) (0.15) | EDMA (3.6) | 1:6:1:24 | IL (1.235) | DMF/DMSO (0.12/0.6) | 16.2/12.3 | 1.32 a |
Mobile phase composition: a ACN; b ACN:50 mM formate buffer, pH 3 = 86:14, v/v. In a typical thermal (60 °C) or photo-induced polymerization (24 h), the pre-polymerization mixture also includes 15 mg of AIBN as free radical initiator. T—template, M—monomer, Me—metal ion, C—cross-linker, A—additive, P—porogen, IL—[BMIM]BF4.