Table 2.
Chromatographic retention (k’) and enantioselectivity (α) of various MIP-CSPs tested in monolithic columns (M1–10) with 4-VPy as functional monomer.
| # | T (mmol) | M(s) (mmol) | Me (mmol) | C (mmol) | Molar Ratio T:M:Me:C | A (mmol) | P (mL) | k’S/k’R | α |
|---|---|---|---|---|---|---|---|---|---|
| M1 | S-ATNL (0.2) | 4-VPy (1) | Co(II) (0.2) | TRIM (6) | 1:5:1:30 | IL (0.9) | DMF/DMSO (0.9/0.9) | 4.3/4.3 | 1.00 |
| M2 | S-ATNL (0.15) | 4-VPy (0.9) | Co(II) (0.15) | EDMA (3.6) | 1:6:1:24 | IL (1.235) | DMF/DMSO (0.12/0.6) | 3.7/2.3 | 1.60 a |
| M3 | S-ATNL (0.15) | 4-VPy (0.9) | Ni(II) (0.15) | EDMA (3.6) | 1:6:1:24 | IL (1.235) | DMF/DMSO (0.12/0.6) | 9.4/6.8 | 1.38 a |
| M4 | S-ATNL (0.15) | 4-VPy (0.9) | Cu(II) (0.15) | EDMA (3.6) | 1:6:1:24 | IL (1.235) | DMF/DMSO (0.48/0.6) | 6.8/5.3 | 1.30 a |
| M5 | S-ATNL (0.15) | 4-VPy (0.9) | Co(II) (0.15) | EDMA (3.6) | 1:6:1:24 | - * | DMF/DMSO (0.326/1.630) | 6.3/5.8 | 1.08 a |
| M6 | S-ATNL (0.15) | 4-VPy (0.9) | - | EDMA (3.6) | 1:6:-:24 | IL (1.235) | DMF/DMSO (0.12/0.6) | 3.4/2.6 | 1.30 a |
| M7 | S-ATNL (0.15) | 4-VPy (0.9) | Co(II) (0.15) | EDMA (3.6) | 1:6:1:24 | IL/PEGMA (1.235/0.17) | DMF/DMSO (0.12/0.6) | 4.0/4.0 | 1.00 |
| M8 | - | 4-VPy (0.9) | Co(II) (0.15) | EDMA (3.6) | -:6:1:24 | IL (1.235) | DMF/DMSO (0.12/0.6) | 2.7/2.6 | 1.04 a |
| M9 | - | 4-VPy (0.9) | - | EDMA (3.6) | -:6:-:24 | IL (1.235) | DMF/DMSO (0.12/0.6) | 10.4/10.4 | 1.00 |
| M10 | S-ATNL (0.05) | 4-VPy (0.15) | Ni(II) (0.05) | TRIM (1.15) | 1:3:1:23 | - | MeOH (2) | 0.3/0.3 | 1.00 |
Mobile phase composition: a ACN. * Replaced with the corresponding volume of DMF/DMSO 1:5, v/v. In a typical thermal (60 °C) or photo-induced polymerization (24 h), the pre-polymerization mixture also includes 15 mg of AIBN as free radical initiator. T—template, M—monomer, Me—metal ion, C—cross-linker, A—additive, P—porogen, IL—[BMIM]BF4.