Table 2.
The percent (%) displacements and the binding affinities (Ki) of compound 16 analogs against CB1 and CB2 receptors in radioligand competition assays.
| Compound | MW | (% Displacement at 10 µM) | Ki ± SEM (μM) | ||
|---|---|---|---|---|---|
| CB1 | CB2 | CB1 | CB2 | ||
| PCB-161 | 436.3 | 37.4 | 44.6 | >10.0 | >10.0 |
| PCB-162 | 436.3 | 3.9 | 28.4 | ND | >10.0 |
| PCB-163 | 454.3 | 72.0 | 81.1 | 0.4870 ± 0.1516 | 1.084 ± 0.141 |
| PCB-164 | 444.4 | 29.8 | 97.2 | NC # | 0.1556 ± 0.0173 |
| PCB-165 | 321.3 | 33.0 | - | >10.0 | - |
| CP55,940 | 376.6 | 0.002162 ± 0.000420 | 0.001185 ± 0.000128 | ||
# “Not converged” means that the binding curve did not fit the expected sigmoidal shape.