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. 2018 Oct 22;23(10):2725. doi: 10.3390/molecules23102725

Table 1.

Substitution pattern of the substituted 3-phenyl-1-thiophen-2-yl-propenone derivatives (1a–h).

graphic file with name molecules-23-02725-i001.jpg

Compounds R1 R2 R3 R4 IC50 (μM) a IC50 (μM) b
1a H H OH H 46.16 ± 0.55 60.05 ± 7.85
1b H OH OH H 75.72 ± 2.46 103.44 ± 8.47
1c OH H OH H 0.013 ± 0.64 0.93 ± 0.22
1d H OMe OH H 98.78 ± 2.11 >200
1e H OH OMe H 17.44 ± 1.81 28.72 ± 1.98
1f H OMe OH OMe 77.91 ± 8.74 >200
1g H Br OH H >200 112.09 ± 14.27
1h H Br OH Br >200 >200
Kojic acid c 22.84 ± 0.09 24.57 ± 0.23

The IC50 values (μM) were calculated from a log dose inhibition curve using l-tyrosine a and l-DOPA b as a substrate, respectively, and are as means ± standard error of the mean (SEM) of triplicate experiments. c Used as positive control.