Table 3.

Tyrosinase inhibitory activity of 1c.

	Binding Energy a (kcal/mol)	No. of H-Bond b	H-Bond Interacting b Residues	Van der Waals Bond Interaction Residues b
1c	−5.9	2	ASN260, MET280	MET257, VAL248, PHE264, VAL283, ALA286
Kojic acid c	−4.2	2	MET280	HIS263

^a Binding energy indicate binding affinity and capacity for the active site of tyrosinase enzyme. ^b The number of hydrogen bonds, and all amino acid residues from the enzyme-inhibitor complex were determined by using AutoDock 4.2 program ^c Reported competitive type inhibitor.