Table 1.

Classification of first-generation antipsychotic drugs: examples and their chemical structures.

Group of Antipsychotic Drugs			Drug Examples
Phenothiazines	Side chain	Aliphatic	Chlorpromazine X = Cl; R =
			Levomepromazine X = OCH3; R =
			Promazine X = H; R =
			Triflupromazine X = CF3; R =
		Piperidine	Mesoridazine X = SOCH3; R =
			Pericyazine X = CN; R =
			Pipotiazine X = SO2N(CH3)2; R =
			Thioridazine X = SCH3; R =
		Piperazine	Fluphenazine X = CF3; R =
			Perphenazine X = Cl; R =
			Prochlorperazine X = Cl; R =
			Trifluoperazine X = CF3; R =
Butyrophenones			Benperidol
			Droperidol
			Haloperidol
Thioxanthenes			Clopenthixol X = Cl; R = mixture of cis and trans isomers
			Flupenthixol X = CF3; R = mixture of cis and trans isomers
			Thiothixene X = SO2N(CH3)2; R = cis isomer
			Zuclopenthixol X = Cl; R = cis isomer
Dihydroindolones			Molindone
Dibenzepines			Clotiapine X = S
			Loxapine X = O
Diphenylbutylpiperidines			Fluspirilene
			Pimozide