Scheme 1.
(a) CHCCH2Br, NaH, DMF; (b) CH2(CO2Et)2, NaH, THF; (c) NH2CH2CH2NH2, 50 °C for 48 h; (d) MeCN, Na2CO3, BrCH2CO2Me, 60 °C for 2 h; (e) (i) NH2CH2CH2NH2, 50 °C for 3 d. (ii) Boc2O, MeOH/Et3N.
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