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. 2018 Jul 31;23(8):1911. doi: 10.3390/molecules23081911

Figure 2.

Figure 2

Variation in serum CK, AST, LDH1, and TBIL during a time course rehabilitation of envenomed mice. (A) Creatine kinase increased significantly at day 1, indicating an immediate muscle necrosis. Varespladib significantly prevented muscle degeneration; (B,C) were serum AST and LDH1 levels, significant increase occurred at the initial 7 days; (D) Total bilirubin, a biomarker of erythrocyte degradation, increased substantially at the 3rd day, the time of hemorrhage removal and absorption. Results were presented as means ± SD (n = 3). * p Venom vs. Venom + Var (p < 0.05), ** p < 0.01, *** p < 0.001,“a” p < 0.05 Venom vs. Vehicle, “b” p < 0.05 Venom + Var vs. Vehicle, “c” p < 0.05 Venom vs. Venom day 1, “d” p < 0.05 Venom + Var vs. Venom + Var day 1.