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The molecular mechanism of PWWP association with nucleic acid. Residues determined to be important for binding nucleic acid as mapped by NMR spectroscopy and/or mutagenesis are shown as cyan sticks on ribbon representations of the LEDGF PWWP structure (PDBID 4FU6). Residues important for histone binding are shown as violet sticks. Corresponding representation of the electrostatic surface (determined using the APBS plug-in in pymol) is shown in two orientations.
