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. 2018 Oct 22;23(10):2723. doi: 10.3390/molecules23102723

Figure 4.

Figure 4

Antagonist of PPARα and PPARγ abolished the effects of nuciferine on the LPS-induced TNFα and IL-6 production. RAW264.7 cells were pretreated with GW6417/GSK0660/GW9662, for 12 h, followed by the nuciferine incubation, for 24 h, and then stimulated with LPS for 12 h. (A,B) production of the IL-6 and the TNFα in a cell medium supernatant. (C,D) mRNA expression of IL-6 and TNFα. * p < 0.05 ** p < 0.01 vs. control. # p < 0.05, ## p < 0.01 vs. LPS treatment. $ p < 0.05 vs. antagonist pretreatment followed by the LPS stimulation.