Table 1.
Nuciferine inhibits the LPS-induced TNFα and IL-6 production in RAW264.7 cells.
| Nuciferine (μM) |
LPS (ng/mL) |
TNFα | IL-6 | ||
|---|---|---|---|---|---|
| Protein (pg/mL) | mRNA | Protein (pg/mL) | mRNA | ||
| 0 | 0 | 380.51 ± 51.27 | 0.99 ± 0.01 | 352.01 ± 60.02 | 1.01 ± 0.01 |
| 0 | 500 | 2584.46 ± 179.60 * | 1.64 ± 0.21 ** | 1663.71 ± 137.20 * | 3.34 ± 0.39 ** |
| 1 | 500 | 2315.98 ± 146.64 | 1.39 ± 0.17 | 1643.94 ± 209.69 | 2.59 ± 0.28 |
| 10 | 500 | 2139.87 ± 275.53 | 1.05 ± 0.13 # | 1216.91 ± 88.18 # | 1.92 ± 0.20 ## |
| 50 | 500 | 1772.82 ± 203.58 ## | 0.61 ± 0.11 ## | 1028.78 ± 74.61 ## | 1.85 ± 0.21 ## |
Quantitative data are presented as mean ± SEM. * p < 0.05 ** p < 0.01 vs. control, # p < 0. 05 ## p < 0.01 vs. LPS treatment.