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. 2018 Oct 7;23(10):2555. doi: 10.3390/molecules23102555

Figure 2.

Figure 2

High-resolution crystal structures for members of the ZF MBP family in complex with their respective methylated DNA targets. (a) Human ZBTB33 in complex with a methylated DNA sequence derived from the E-cadherin promoter (PDB 4F6N); (b) mouse Zfp57 in complex with a methylated DNA sequence present in imprinting control regions (PDB 4GZN); (c) mouse Klf4 (Krüppel-like factor 4) in complex with its cognate methylated DNA sequence (PDB 4M9E); (d) human Egr1 (growth response protein 1) in complex with its cognate methylated DNA sequence (PDB 4X91); (e) human CTCF (CCCTC-binding factor) in complex with a methylated version of its core recognition sequence (PDB 5T00). Red spheres indicate water molecules. Red dotted lines denote classical hydrogen bond interactions; blue dotted lines indicate CH···O type hydrogen bonds, and black dotted lines designate van der Waals interactions. For each zoomed-in image, the amino acid side chain color designation matches that of the ZF from which it is derived in the full structural image depicted above.