Table 7.
The in vitro activity (MIC values in μM units) of investigated compounds 1a–p and reference drugs isoniazid (INH), ethambutol (EMB), ofloxacin (OFLX) and ciprofloxacin (CPX) against M. avium CNCTC My 330/80 (MA 330/80), M. smegmatis ATCC 700084 (MS) and M. marinum CAMP 5644 (MM), respectively.
| Comp. | MIC [μM] | |||
|---|---|---|---|---|
| MA 330/80 | MS | MM | ||
| 1 14-d | 2 21-d | 3 3-d | 21-d | |
| 1a | 125 | 125 | 213 | 106 |
| 1b | 62.5 | 125 | 104 | 52 |
| 1c | 32 | 62.5 | 51 | 25.5 |
| 1d | 32 | 32 | 24.9 | 12.5 |
| 1e | 62.5 | 62.5 | 16.2 | 32.5 |
| 1f | 32 | 32 | 15.8 | <3.9 |
| 1g | 16 | 16 | 15.4 | <3.8 |
| 1h | 8 | 16 | 15.0 | <3.7 |
| 1i | 62.5 | 125 | 203 | 51 |
| 1j | 62.5 | 125 | 6.2 | 50 |
| 1k | 32 | 62.5 | 390 | 98 |
| 1l | 32 | 62.5 | 382 | 191 |
| 1m | 16 | 32 | 30.7 | 15.4 |
| 1n | 16 | 16 | 15.0 | 15.0 |
| 1o | 16 | 16 | 7.3 | 7.3 |
| 1p | 16 | 16 | 7.1 | 7.1 |
| INH | > 250 | > 250 | 117 | 467 |
| EMB | 16 | 16 | – | – |
| OFLX | 32 | 62.5 | – | – |
| CPX | – | – | 0.4 | 0.8 |
1 14-d, 14-Day cultivation; 2 21-d, 21-day cultivation; 3 3-d, 3-day cultivation. The most promising values of compounds´ in vitro antimycobacterial activity (MIC ≤ 8 μM) were indicated in gray cells of Table 7.