Table 1.
IC50 values of DUQ0008 crude extract and fractions at active receptors.
| 5-HT1A (IC50) | 5-HT2A (IC50) | 5-HT2C (IC50) | 5-HT7 (IC50) | Alpha2B (IC50) | D1 (IC50) | D5 (IC50) | DOR (IC50) | σ2R (IC50) | |
|---|---|---|---|---|---|---|---|---|---|
| Crude | - | - | - | - | - | - | - | - | 722.0 ± 0.8 |
| A | - | - | - | - | - | - | - | - | - |
| B | - | - | - | - | - | - | - | - | - |
| C | - | - | 191.0 ± 0.8 | - | - | 5083.0 ± 0.9 | - | - | - |
| D | - | >10,000 | - | - | 1999.7 ± 0.8 | - | - | 1776.0 ± 0.9 | - |
| E | - | - | - | - | - | - | - | - | 1502.0 ± 0.8 |
| F | - | - | - | - | - | - | - | - | - |
| G | - | 1854.0 ± 0.9 | 98.0 ± 0.8 | - | 2030.0 ± 0.8 | 1526.0 ± 0.9 | 1531.0 ± 0.9 | 1618.0 ± 0.9 | 1085.0 ± 0.8 |
| H | - | - | - | - | - | - | - | - | 1874.0 ± 0.8 |
| I | 2441.0 ± 0.8 | - | - | 1223.00 ± 0.8 | - | - | - | - | 424.0 ± 0.8 |
Open boxes with - indicate that fractions failed primary binding criterion of >50% inhibition at 10 mg/mL. N = 3 separate determinations for each value. All data presented as ng/mL.