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. 2018 Aug 20;23(8):2084. doi: 10.3390/molecules23082084

Table 1.

SAR of all target compounds for anti-EV71 activity and cytotoxicity in Vero cells.

graphic file with name molecules-23-02084-i001.jpg

No. R TC50 a H Strain JS-52 Strain SHZH98 Strain BrCr Strain
IC50 a SI b IC50 a SI IC50 a SI IC50 a SI
BBR - 147 21.2 6.93 14.0 10.5 28.2 5.22 9.45 15.6
1 - 85.5 37.0 2.31 28.5 3.00 32.6 2.62 35.4 2.41
3 - 254 121 2.10 102 2.50 132 1.93 135 1.87
JTH - 255 >147 - 147 1.73 147 1.73 >147 -
2a graphic file with name molecules-23-02084-i002.jpg 223 48.3 4.62 45.5 4.89 60.4 3.69 32.3 6.90
2b graphic file with name molecules-23-02084-i003.jpg 22.3 >5.34 - 5.73 3.89 5.46 4.08 2.04 10.9
2c graphic file with name molecules-23-02084-i004.jpg 27.9 13.8 2.02 7.26 3.84 8.59 3.24 4.26 6.54
2d graphic file with name molecules-23-02084-i005.jpg 82.8 12.4 6.70 7.12 11.6 14.8 5.58 8.52 9.72
2d-a graphic file with name molecules-23-02084-i006.jpg 437 >145 - 145 3.00 >145 - 145 3.00
2e graphic file with name molecules-23-02084-i007.jpg 14.4 >5.31 - 2.67 5.40 2.84 5.08 2.23 6.47
2f graphic file with name molecules-23-02084-i008.jpg 9.22 >5.33 - 1.61 5.74 1.85 4.97 2.21 4.17
2g graphic file with name molecules-23-02084-i009.jpg 54.9 15.8 3.47 11.9 4.62 12.3 4.46 10.6 5.18
2h graphic file with name molecules-23-02084-i010.jpg 124 >47.9 - >47.9 - >47.9 - 47.9 2.59
2i graphic file with name molecules-23-02084-i011.jpg 167 31.1 5.37 43.6 3.83 45.7 3.65 33.6 4.97
4a graphic file with name molecules-23-02084-i012.jpg 434 144 3.01 >144 - >144 - >144 -
4b graphic file with name molecules-23-02084-i013.jpg 333 >144 - 109 3.05 >144 - 144 2.32
4c graphic file with name molecules-23-02084-i014.jpg 452 >143 - 99.3 4.55 >143 - 81.1 5.57
4d graphic file with name molecules-23-02084-i015.jpg 50.0 >15.9 - 44.2 1.13 >47.8 - 44.2 1.13
4e graphic file with name molecules-23-02084-i016.jpg 143 13.6 10.5 19.4 7.35 27.6 5.18 17.1 8.36
4f graphic file with name molecules-23-02084-i017.jpg 306 82.2 3.73 54.2 5.65 82.2 3.73 66.0 4.64
4g graphic file with name molecules-23-02084-i018.jpg 351 >143 - 129 2.72 >143 - >143 -
5a graphic file with name molecules-23-02084-i019.jpg 250 130 1.93 109 2.29 144 1.74 125 2.01
5b graphic file with name molecules-23-02084-i020.jpg 83.3 41.3 2.02 34.2 2.44 69.3 1.20 34.2 2.44
5c graphic file with name molecules-23-02084-i021.jpg 248 93.7 2.65 101 2.46 123 2.01 44.1 5.62
5d graphic file with name molecules-23-02084-i022.jpg 41.0 >15.9 - 9.01 4.55 12.0 3.41 >15.9 -
5e graphic file with name molecules-23-02084-i023.jpg 27.6 10.4 2.65 8.69 3.18 9.13 3.03 9.20 3.01
5f graphic file with name molecules-23-02084-i024.jpg 143 40.4 3.54 27.0 5.36 68.4 2.09 25.4 5.63
5g graphic file with name molecules-23-02084-i025.jpg 265 143 1.85 51.3 5.16 86.7 3.05 82.8 3.19

a The unit of μM was used to measure TC50 (median toxic concentration) and IC50 values which are calculated based on the organic part of the target compounds. The average values of three batches were shown in this table (n = 3). b SI was calculated as the ratio of TC50 and IC50.