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. 2018 Sep 4;8(11):3489–3497. doi: 10.1534/g3.118.200619

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Copyright © 2018 Battlay et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Functional validation of insecticide resistance candidates. Insecticide LD₅₀s for both male and female adults. Error bars represent 95% confidence interval. Blue bars represent males and pink bars represent females. CRISPR knockout of Cyp6g1 in the DGRP line RAL_517 background significantly increases susceptibility to organophosphate insecticides malathion, azinphos-methyl and diazinon. Transgenic overexpression of Cyp12d1 with the 6g1HR-GAL4 driver significantly increases resistance to malathion. Gene Disruption Project line Cyp6a17^KG04448 shows increased permethrin susceptibility.