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. 2018 Oct 17;23(10):2668. doi: 10.3390/molecules23102668

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of bergenin on splenic T lymphocyte subsets in the Cy-treated mice. (A) CD3⁺, CD4⁺ and CD8⁺ T lymphocyte expression in spleen tissues. (B) Bar graphs represent mean ± SEM of the numbers of CD3⁺-positive cells from five microscopic fields in each group. (C) Bar graphs represent mean ± SD of the numbers of CD4⁺-positive cells from five microscopic fields in each group. (D) Bar graphs represent mean ± SEM of the numbers of CD8⁺-positive cells from five microscopic fields in each group. (E) Splenic T lymphocyte subsets detected by flow cytometry. (F) Splenic T lymphocyte subpopulation analyzed by flow cytometry. NC: normal control group, dosed with saline; MC: model control group, challenged with cyclophosphamide; Be-L: challenged with Cy and treated with 5 mg/kg/day bergenin; Be-M: challenged with Cy and treated with 10 mg/kg/day bergenin; Be-H: challenged with Cy and treated with 20 mg/kg/day bergenin. Values are shown as mean ± SD (n = 8). ^# p < 0.05, ^## p < 0.01 vs. the NC group, * p < 0.05 and ** p < 0.01 vs. the MC group.

Effects of bergenin on splenic T lymphocyte subsets in the Cy-treated mice. (A) CD3⁺, CD4⁺ and CD8⁺ T lymphocyte expression in spleen tissues. (B) Bar graphs represent mean ± SEM of the numbers of CD3⁺-positive cells from five microscopic fields in each group. (C) Bar graphs represent mean ± SD of the numbers of CD4⁺-positive cells from five microscopic fields in each group. (D) Bar graphs represent mean ± SEM of the numbers of CD8⁺-positive cells from five microscopic fields in each group. (E) Splenic T lymphocyte subsets detected by flow cytometry. (F) Splenic T lymphocyte subpopulation analyzed by flow cytometry. NC: normal control group, dosed with saline; MC: model control group, challenged with cyclophosphamide; Be-L: challenged with Cy and treated with 5 mg/kg/day bergenin; Be-M: challenged with Cy and treated with 10 mg/kg/day bergenin; Be-H: challenged with Cy and treated with 20 mg/kg/day bergenin. Values are shown as mean ± SD (n = 8). ^# p < 0.05, ^## p < 0.01 vs. the NC group, * p < 0.05 and ** p < 0.01 vs. the MC group.