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. 2018 Aug 16;23(8):2051. doi: 10.3390/molecules23082051

Table 1.

Optimization of the reaction conditions.

graphic file with name molecules-23-02051-i001.jpg

Entry Reactant Reaction Conditions x Time/Temp (°C) Yield a (%)
1 2a Pd(PPh3)4/Na2CO3 2 40 min/120 60
2 1a Pd(PPh3)4/Na2CO3 2 40 min/120 75
3 1a Pd(OAc)2/XantPhos, K3PO4 2 40 min/120 20
4 1a Pd(OAc)2, Na2CO3 2 40 min/120 34
5 1a Pd(PPh3)2Cl2/PPh3, Na2CO3 2 40 min/120 50
6 1a NiCl2(dppe)/dppe, K3PO4 2 40 min/120 20
7 1a Pd(PPh3)4/Na2CO3 1 40 min/120 48
8 1a Pd(PPh3)4/Na2CO3 3 40 min/120 59
9 1a Pd(PPh3)4/Na2CO3 2 40 min/180 68
10 1a Pd(PPh3)4/Na2CO3 2 60 min/120 34

Reaction conditions: 5 mol % of catalyst, aqueous base, 1,4-dioxane, µW. a Yield corresponding to the purified products.