Table 2.
Activities of essential oils of Baccharis species against Plasmodium falciparum.
| Sample Name | P. falciparum (D6 Clone) | P. falciparum (W2 Clone) | Cytotoxicity (Vero Cells) IC50 (µg/mL) |
||
|---|---|---|---|---|---|
| IC50 (µg/mL) | SI | IC50 (µg/mL) | SI | ||
| B. microdonta | 14.75 ± 3.80 | 2.4 | 23.93 ± 4.64 | 1.5 | 35.80 ± 7.29 |
| B. pauciflosculosa | 10.90 ± 0.98 | >4.3 | 14.20 ± 1.08 | >3.3 | NC |
| B. punctulata | 17.26 ± 0.83 | 2.2 | 19.73 ± 4.11 | 1.9 | 37.81 ± 6.36 |
| B. reticularioides | 20.32 ± 4.37 | >2.3 | 34.35 ± 10.15 | >1.4 | NC |
| B. sphenophylla | 27.58 ± 1.64 | >1.7 | 32.53 ± 16.5 | >1.5 | NC |
| Chloroquine | 0.014 | >17 | 0.117 | >2 | NC |
| Artemisinin | 0.004 | >31.8 | 0.003 | >71.3 | NC |
NC: No cytotoxicity up to 47.6 μg/mL of essential oils and 0.238 µg/mL for chloroquine and artemisinin; SI: selectivity index (IC50 for cytotoxicity/IC50 for antimalarial activity); values were measured in triplicate (n = 3). They are presented as mean ± SD.