Table 1.
Pharmacokinetic parameters of FD4 after pulmonary administration with different concentrations and generations of the PAMAM dendrimer to rats.
| Cmax (μg/mL) | Tmax (min) | AUC0–120 (μg∙min/mL) | E. Ratio | |
|---|---|---|---|---|
| Control | 2.1 ± 0.2 | 170.0 ± 43.6 | 374.3 ± 36.3 | 1.0 |
| 0.5% G0 | 2.2 ± 0.2 | 170.0 ± 43.6 | 327.5 ± 23.2 | 0.9 |
| 0.1% G1 | 2.4 ± 0.3 | 120.0 ± 34.6 | 398.0 ± 62.3 | 1.1 |
| 0.5% G1 | 2.9 ± 0.4 * | 127.5 ± 18.9 | 503.8 ± 51.8 * | 1.3 |
| 1% G1 | 3.6 ± 0.4 * | 135.0 ± 26.0 | 611.3 ± 68.3 ** | 1.6 |
| 0.1% G2 | 3.6 ± 0.3 * | 80.0 ± 20.0 | 73.7 ± 30.1 ** | 1.8 |
| 0.5% G2 | 5.0 ± 0.4 ** | 90.0 ± 17.3 | 894.2 ± 55.7 ** | 2.4 |
| 1% G2 | 5.5 ± 0.5 ** | 120.0 ± 0.0 | 921.8 ± 106.6 ** | 2.5 |
| 0.1% G3 | 4.4 ± 0.2 ** | 100.0 ± 10.0 | 728.5 ± 43.6 ** | 2.0 |
| 0.5% G3 | 6.0 ± 0.4 ** | 90.0 ± 13.5 * | 996.2 ± 74.4 ** | 2.7 |
| 1% G3 | 7.0 ± 0.5 ** | 102.0 ± 12.0 | 1103.0 ± 55.9 ** | 2.9 |
Note: The results are expressed as the mean ± S.E. of 3–5 experiments. (**) p < 0.01, (*) p < 0.05, compared with the control group. Cmax: peak concentration; Tmax: peak time; AUC0–120: area under the concentration-time curve from zero to 120 min; E. Ratio: absorption enhancement ratio.