Table 2.
Pharmacokinetic parameters of FD10 and FD70 after pulmonary administration with the 0.5% (w/v) G2 and G3 dendrimer to rats.
| Cmax (μg/mL) | Tmax (min) | AUC0→12 (μg·min/mL) | E. Ratio | |
|---|---|---|---|---|
| FD10 | ||||
| Control | 1.1 ± 0.1 | 150.0 ± 26.9 | 160.8 ± 16.9 | 1.0 |
| 0.5% G2 | 2.3 ± 0.3 | 130.0 ± 26.5 | 422.5 ± 46.4 ** | 2.6 |
| 0.5% G3 | 4.8 ± 0.2 | 130.0 ± 26.5 | 777.7 ± 11.0 ** | 4.8 |
| FD70 | ||||
| Control | 0.2 ± 0.0 | 22.2 ± 2.4 | 1.0 | |
| 0.5% G2 | 1.8 ± 0.2 | 200.0 ± 20.0 | 247.0 ± 13.7 ** | 11.1 |
| 0.5% G3 | 1.8 ± 0.1 | 180.0 ± 0.0 | 309.1 ± 22.8 ** | 13.9 |
The results are expressed as the mean ± S.E. of 3–5 experiments. (**) p < 0.01, compared with the control group.