Figure 3.

(a–c) H6/H5′′ of C and H8/H1′ of G (8CH₃/H1′ of m⁸Gm) proton region of NOESY spectra of r(CGC[m⁸Gm]CG)₂ in NaClO₄ solution. The NOE connectivity pathway is shown as red line. Intraresidue NOE cross-peaks are labeled with residue numbers. The Z-RNA structure specific cross-peaks were observed between C₅ amino protons and C₁H5 protons from the opposite strand (indicated as red words), as well as between C₁ amino protons and C₅H5 protons from the opposite strand (c). (d) The cross peaks of imino proton of G₂ and amino proton of C₅, as well as imino proton of G₆ and amino proton of C₁, indicated Watson–Crick-type base pairs of Z-RNA. Intraresidue NOE cross-peaks of imino and amino proton of G₂ and G₆ are shown.