Table 2.

Thermodynamic parameters from ITC analysis of compounds 1, 3–9.

Compound	KD (nM−1)	ΔG (kcal M−1)	ΔH (kcal M−1)	−TΔS (kcal M−1)
1	2376.1 ± 214.4 *	−7.42 *	0.36 *	7.77 *
3	721.4 ± 120.1 *	−8.10 *	1.14 *	9.24 *
4	18.5 ± 13.9 1	−10.20	2.16	12.36
	155.0 ± 130.9 2	−8.98	0.28	9.26
5	6.9 ± 1.4 1	−10.38	10.01	20.39
	281.1 ± 38.7 2	−8.25	2.55	10.80
6	69.0 ± 12.0 1	−9.45	49.4	58.85
	193.4 ± 30.5 2	−8.88	0.31	9.17
7	16.2 ± 8.9 1	−10.27	9.29	19.56
	127.6 ± 56.7 2	−9.09	0.23	9.32
8	4.1 ± 2.5 1	−11.07	2.31	13.38
	374.0 ± 102.0 2	−8.48	0.51	8.99
9	35.0 ± 19.7 1	−9.83	6.01	15.84
	372.1 ± 212.8 2	−8.48	1.18	9.66

* data are taken from reference [35]. ¹ K_D belongs to the first binding stage. ² K_D belongs to the second binding stage.