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. 2018 Jul 25;23(8):1849. doi: 10.3390/molecules23081849

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effect of caspase inhibitors on (−)-asarinin (1)-induced cell death in human ovarian cancer cells. A2780 (A) and SKOV3 (B) cells were pretreated with caspase-3 inhibitor z-DEVD-fmk (50 μM), caspase-8 inhibitor z-IETD-fmk (50 μM), and caspase-9 inhibitor z-LEHD-fmk (50 μM) for 30 min, and then treated with the indicated concentration (A2780; 40 μM and SKOV3; 60 μM) of (−)-asarinin (1) for 48 h. A MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide) assay was performed to determine the cell viability after (−)-asarinin (1) treatment. Statistical significance was determined by Student’s t-test. # p < 0.05 as compared with the untreated group and * p < 0.05 as compared with the (−)-asarinin (1) only-treated group.