Table 2.
Cytotoxicity of compounds 1–8 from the EtOAc-soluble fraction of the roots of A. sieboldii in human ovarian cancer cells (A2780 and SKOV3) and immortalized ovarian surface epithelial cells (IOSE80PC).
| Compound | IC50 (μM) * | ||
|---|---|---|---|
| Human Ovarian Cancer Cells | Immortalized Ovarian Surface Epithelial Cells | ||
| A2780 | SKOV3 | IOSE80PC | |
| 1 | 38.45 ± 2.78 | 60.87 ± 5.01 | >200 |
| 2 | 101.85 ± 13.55 | 173.82 ± 9.42 | 178.92 ± 3.30 |
| 3 | >200 | >200 | >200 |
| 4 | >200 | >200 | >200 |
| 5 | ND ** | ND ** | ND ** |
| 6 | >200 | >200 | >200 |
| 7 | >200 | >200 | >200 |
| 8 | 101.20 ± 10.35 | >200 | >200 |
| Cisplatin *** | 8.77 ± 0.48 | 24.18 ± 0.28 | 45.62 ± 0.30 |
* IC50 value is defined as the concentration that results in a 50% decrease in the proliferation of the cells. The values represent the means of the results from three independent experiments with similar patterns. ** Not determined since the amount of available compound was insufficient. *** Cisplatin was used as an assay positive control.