Figure 3.

Determination of apoptosis and necrosis potential of synthesized compounds on HEK293, PC-3, HCT116 and T47D cell lines. (A) Compounds tested on HEK293 cell line did not exhibit any cytotoxic effects, except compound 10 with a slight insignificant increase in necrosis; (B) Treatment of PC-3 cells with compounds 6 and 10 resulted in increase of late apoptosis markers; (C) Compound 16 displayed extensive apoptotic effects (both early and late markers were elevated) on the HCT116 cancer cell line; (D) T47D cancer cells underwent vast late apoptosis through the treatment with compound 15, whereas compound 16 caused necrosis of T47D cancer cells (* p < 0.05, ** p < 0.01, *** p < 0.001).