Table 2.

Kinetics and affinity of BMS-626529 and the SC compounds binding to soluble, cleaved recombinant Env.

Compound	ka (M−1 s−1)	kd (s−1)	KD
BMS-626529 *	3.89 × 104	5.9 × 10−4	15.2 nM
SC11	4.33 × 103	2.87 × 10−4	66.3 nM
SC16	8.62 × 104	5.98 × 10−3	69.3 nM
SC18	1.59 × 104	2.48 × 10−2	1.56 μM
SC39	1.39 × 103	3.81 × 10−2	27.4 μM

* The sensorgrams for BMS-626529 binding to soluble, cleaved recombinant Env are shown in Supplementary Materials.