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. 2018 Sep 26;23(10):2465. doi: 10.3390/molecules23102465

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Domain architecture and multiple sequence alignment of PDZ proteins from cell-cell junctional protein complexes. (a) domain architectures of mouse ZO-1, ZO-2, ZO-3, and afadin (AF6). PDZ, PDZ domain; SH3, Src homology 3 domain; GK, guanylate kinase domain; ZU5, ZO-1 and UNC5 domain; RA, Ras associating domain; FHA, forkhead-associated domain; DIL, dilute domain, and PR, proline-rich region. (b) multiple sequence alignment of selected PDZ domains. The first PDZ domains from ZO-1/2/3 proteins, PDZ domains from afadin and Par3, and the second PDZ domain from LNX1 were aligned. Protein names and UniProtKB accession numbers are as follows: ZO-1 mouse (P39447); ZO-2 mouse (Q9WV86); ZO-3 mouse (Q9VN89); LNX1p80 mouse (Q9SEX2); afadin mouse (Q9BW62); ZO-1 human (Q07157), ZO-1 rat (F1M4A0), and Par3 mouse (Q99NH2). The sequence alignment was generated by ClustalX [11].