Table 4.

Performance comparison of different features on the independent test dataset (BID18).

Methods	Features	SPE	SEN	PRE	ACC	F1	MCC	AUC
SVM	Physicochemical	0.577	0.393	0.597	0.583	0.472	0.162	0.634
	PSSM	0.675	0.438	0.561	0.640	0.491	0.223	0.663
	Blocks substitution matrix	0.626	0.435	0.632	0.628	0.512	0.242	0.661
	ASA	0.597	0.446	0.716	0.634	0.549	0.290	0.693
	Solvent exposure	0.642	0.403	0.532	0.608	0.456	0.167	0.617
	Combined	0.569	0.464	0.832	0.650	0.586	0.353	0.732
RF	Physicochemical	0.632	0.414	0.576	0.614	0.479	0.196	0.624
	PSSM	0.703	0.417	0.474	0.632	0.443	0.171	0.616
	Blocks substitution matrix	0.62	0.408	0.575	0.607	0.474	0.185	0.627
	ASA	0.604	0.437	0.686	0.629	0.534	0.268	0.679
	Solvent exposure	0.59	0.402	0.612	0.597	0.484	0.188	0.64
	Combined	0.612	0.466	0.753	0.656	0.575	0.338	0.758
GTB	Physicochemical	0.531	0.384	0.643	0.566	0.478	0.163	0.625
	PSSM	0.681	0.416	0.506	0.627	0.456	0.178	0.638
	Blocks substitution matrix	0.580	0.400	0.617	0.592	0.480	0.184	0.624
	ASA	0.585	0.437	0.718	0.626	0.543	0.280	0.679
	Solvent exposure	0.592	0.389	0.579	0.588	0.465	0.159	0.646
	Combined	0.621	0.476	0.766	0.666	0.597	0.378	0.769