Table 1.
The regression equations, linear ranges, and LLOQ for the determination of the alkaloids in the beagle dog plasma. (n = 7).
| Compound | Regression Equation | r 2 | Linear Range (ng/mL) | LLOQ (ng/mL) |
|---|---|---|---|---|
| corydaline | Y = 1.395 × 10−3X + 1.874 × 10−3 | 0.9938 | 0.54–557.0 | 0.54 |
| dehydrocorydaline | Y = 9.668 × 10−4X + 3.035 × 10−3 | 0.9912 | 0.25–257.5 | 0.25 |
| tetrahydropalmatine | Y = 1.368 × 10−3X − 2.608 × 10−4 | 0.9810 | 0.50–507.0 | 0.50 |
| protopine | Y = 4.086 × 10−4X − 3.221 × 10−5 | 0.9870 | 0.53–540.0 | 0.53 |
| palmatine | Y = 4.409 × 10−4X − 7.801 × 10−5 | 0.9868 | 0.51–525.0 | 0.51 |
| tetrahydroberberine | Y = 6.810 × 10−4X + 1.381 × 10−4 | 0.9801 | 0.41–420.0 | 0.41 |
| columbamine | Y = 4.941 × 10-4X − 1.679 × 10−4 | 0.9936 | 0.39–400.0 | 0.39 |
| berberine | Y = 1.667 × 10−3X + 6.950 × 10−3 | 0.9888 | 0.53–540.0 | 0.53 |
| coptisine | Y = 3.263 × 10−4X + 5.393 × 10−3 | 0.9934 | 0.49–500.0 | 0.49 |
| berberrubine | Y = 1.623 × 102X − 2.685 × 10−3 | 0.9816 | 0.22–230.0 | 0.22 |