Table 5.

Pharmacokinetic parameters of the 10 alkaloids in the beagle dog after oral administration of C. yanhusuo (A) and YHZT (B), respectively. (mean ± SD, n = 6).

	Compounds	Cmax (ng/mL)	Tmax (h)	t1/2 (h)	AUC0→t (ng·h/mL)	AUC0→∞ (ng·h/mL)
(A)	corydaline	138 ± 24.5	0.29 ± 0.10	4.90 ± 0.70	358.34 ± 39.02	401.61 ± 48.38
	dehydrocorydaline	99.7 ± 12.3	0.54 ± 0.10	5.83 ± 1.75	342.28 ± 9.30	403.19 ± 30.18
	tetrahydropalmatine	169 ± 55.3	0.54 ± 0.10	9.09 ± 2.17	424.21 ± 20.94	591.20 ± 50.58
	protopine	89.4 ± 8.49	0.95 ± 0.13	5.75 ± 0.81	275.69 ± 18.43	349.18 ± 38.33
	palmatine	116 ± 13.9	0.95 ± 051	4.45 ± 0.71	397.05 ± 30.16	465.14 ± 34.69
	tetrahydroberberine	154 ± 24.9	0.50 ± 0.16	7.06 ± 1.35	711.63 ± 56.12	1044.40 ± 68.18
	columbamine	144 ± 11.01	0.54 ± 0.10	5.67 ± 1.95	404.21 ± 15.57	506.82 ± 40.75
	berberine	187 ± 23.4	0.54 ± 0.10	5.00 ± 0.90	593.56 ± 23.76	673.64 ± 29.62
	coptisine	242 ± 58.2	0.79 ± 0.10	5.89 ± 1.07	631.90 ± 86.03	748.34 ± 68.39
	berberrubine	72.1 ± 1.9	0.54 ± 0.10	5.01 ± 0.61	422.88 ± 23.26	440.26 ± 19.33
(B)	corydaline	165 ± 21.3 *	0.29 ± 0.10	11.24 ± 1.49	361.474 ± 43.83	435.90 ± 58.28
	dehydrocorydaline	187 ± 23.8 *	0.54 ± 0.10	5.61 ± 1.05	1306.88 ± 148.77 *	1399.25 ± 142.40 *
	tetrahydropalmatine	277 ± 23.7 *	0.71 ± 0.10	9.34 ± 0.26	1268.11 ± 61.64 *	1462.37 ± 98.46 *
	protopine	139 ± 24.2 *	0.38 ± 0.14	7.77 ± 0.81	601.27 ± 66.95 *	683.25 ± 67.68 *
	palmatine	127 ± 14.6	0.50 ± 0.16	6.09 ± 0.66	638.87 ± 43.52 *	684.56± 60.57 *
	tetrahydroberberine	145 ± 12.0	0.54 ± 0.10	7.65 ± 1.14	637.16 ± 59.08	718.80 ± 98.29
	columbamine	120 ± 83 *	0.54 ± 0.10	11.73 ± 2.92	611.24 ± 53.13 *	755.66 ± 95.47 *
	berberine	± 28.0 *	0.71 ± 0.10	8.48 ± 1.92	988.42 ± 116.18 *	1140.97 ± 91.92 *
	coptisine	133 ± 15.1 *	0.46 ± 0.10	9.58 ± 1.81	685.60 ± 60.34	824.82 ± 106.82
	berberrubine	86.0 ± 6.7 *	0.54 ± 0.10	5.05 ± 0.48	445.44 ± 27.44	464.11 ± 25.40

The Cmax value, AUC_0→t and AUC_0→∞ compared with C. yanhusuo group * p < 0.05.