pH |
Adjust the isoelectric point of the chitosan derivative to the expected point and reverse the charge under a certain pH condition. Simultaneously, keep the drug delivery system stable in the body fluid circulation and release the drug in response to the pH of the specific sites. |
Arginine |
[45] |
Lysine |
[50] |
Vitamin B12 |
[73] |
Succinylation |
[90,92] |
Gly-Phe-Leu-Gly (GFLG) tetrapeptide |
[82] |
Ethylenediaminetetraacetic acid (EDTA) |
[93] |
Dimethylmaleic anhydride (DMMA) |
[94] |
Cis-aconitic anhydride (CA) |
[95] |
Poly(2-(diisopropylamino)ethyl methacrylate) |
[65] |
Poly(methyl methacrylate) |
[91] |
Polyacrylic acid (PAA) |
[96] |
Temperature |
Act as a hydrophobic core and release drug with temperature responsive. |
pNIPAA |
[88,90] |
Pluronics |
[97] |
Enzyme |
Controlled drug release via structural collapse caused by enzymatic degradation. |
GFLG peptide |
[82] |
Magnetic field |
Direct delivery of the nanoparticle to specific site though external magnetic field. |
Fe3O4
|
[88] |